Case Study:
Animal Model Based Research
Requirements
- Ability to support non-human subjects and their associated data
Functional Narrative
The Researcher monitors the tumor's growth with regular PET scans and archives the images.
The Researcher begins treating the tumor with an experimental protocol of chemotherapy drugs and monitors the tumor's growth with regular lab tests and archives the subject's lab results.
Solution Narrative
Dr. Johnson is a research clinician who is performing a study to apply animal based model research as part of a personalized medicine protocol for patients with lung cancer. He analyzes the molecular profile of a patient's tumor and uses XB-BIS drug knowledge to identify the most likely drug candidates. He then xenografts the patient's tumor onto nude mice, treats the xenografts with the top candidates and prescribes patient treatment based on the effectiveness results observed in the mice. Last, he profiles the tumors in the mice and analyzes the molecular data cross species.
1. A tumor sample is taken from a patient's lung. The sample is tracked in the LabVantage system.
2. The sample tracking data in LabVantage migrates to the hub and automatically is propagated to Dr. Johnson's XB-BIS spoke data mart.
3. Dr. Johnson views the lung sample in XB-BIS.
4. Dr. Johnson performs a molecular experiment on the tumor and loads the gene expression results into XB-BIS (following the steps in the case study "Molecular Analysis of Genomic Data Sets").
5. Dr. Johnson uses XB-BIS to generate a personalized pharmacological report for the patient's lung tumor. The report predicts the effectiveness of drug compounds that target the patient's molecular profile.
6. Dr. Johnson's lab xenografts the tumor onto three nude mice and waits for the tumor to progress in the host mice. The screenshot below shows XB-BIS supports multiple species as well as cell lines.
7. This screenshot illustrates how XB-BIS tracks the donating patient's tumor sample.
8. Dr. Johnson treats the mice with the top three drug recommendations in the patient's personalized medicine report. Throughout the six-week period, Dr. Johnson uses XB-BIS to maintain treatment regimen, images and other phenotype to monitor and track progress in the mice.
9. Dr. Johnson incorporates treatment responses observed in the mice and prescribes the next line of treatment for the patient.
10. In addition, Dr. Johnson acquires samples from the mice, runs molecular experiments and uses XB-BIS to analyze the mouse model against the human model. XB-BIS supports cross species mapping in the genome to support cross species analysis. The cluster below indicates 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGCR) exhibit a similar profile in mice and humans.
